90 Day
Insulin Balance Metabolic Health and Weight Optimization Protocol
| STUDY TITLE | Insulin Balance Metabolic Health and Weight Optimization Protocol |
|---|---|
| Submitted under umbrella | |
| Date submitted |
Aug 12, 2025 |
| End date |
There is no pre-specified end date and sub-studies remain open long-term. |
| Language |
English |
| Efforia AI IRB approval recommendation | |
| Recruitment page preview | |
| Author edit | |
| Informed consent | |
| Study author |
Elwin Robinson, Matthew Amsden |
| Principal investigator |
Matthew Amsden |
| Sub-Investigator for Adverse Events |
Dr. Viral Patel |
| Description |
This protocol involves the daily use of the Insulin Balance Formula to enhance metabolic health, optimize weight and potentially reduce the risk of diabetes. It aims to support blood sugar management, weight optimization, and vitality. Participants will engage in specific tasks to assess the impact of the supplement on their overall metabolic health. |
| Participant engagement length |
90 Days |
| Sponsor |
This study is made possible by your payment to cover all supplies and expenses required to participate. |
| Cost to participant |
$117 |
| Included products & services |
Insulin Balance Formula – Hormetics Weight Optimization System – 3 bottles: $117
|
| Outcome measures |
Body Composition Measurement Form After Food Glucose Follow Up |
| Methodology |
Single Arm longitudinal where participants act as their own control |
| Basic or advanced dissemination plan |
Basic |
| Deviation from recruitment approach |
No |
| Deviation from statistical approach |
No |
| Will study include “more about you questions” |
No |
| Clinicaltrials.Gov |
Yes |
| Committment to list findings on clinicaltrials.Gov |
Yes |
Preview This document is prepared with the assistance of AI, but is reviewed by a human.
Rational & Study Design
**Why I created this study:
** While consulting with Dr Miriam Mikicki MD, who is the co-creator of this formula, I was surprised to see how often, when you help balance people's hormones, any excess weight comes off effortlessly. Since then I have spoken to countless healthcare professionals that focus on hormonal optimization and discovered this is common knowledge. And yet most people have no idea! They still believe that all that matters is diet and exercise. While those factors are obviously important, it turns out that hormonal balance is very important too, and Insulin is perhaps the most important hormone of all for optimal weight and body composition. The reason this isn't common knowledge among the general population is because there are too few studies proving the importance of hormonal optimization for body composition. Our study will scientifically validate its efficacy and explore how it can transform metabolic health, optimize weight, and potentially lower diabetes risk.
**My Objective for You:** Our primary aim is to empower you with personalized insights into how the Insulin Balance Formula can enhance your metabolic health. By the end of this study, you'll have a detailed understanding of your body composition and insulin response, helping you make informed decisions about your health journey. We want you to walk away with a clear path to optimized weight and vitality, tailored to your unique metabolic fingerprint.
**Aims & Objectives:** This study aims to evaluate the effectiveness of the Insulin Balance Formula in improving metabolic health and optimizing weight. Participants will receive personalized results, enabling them to see the direct impact of this protocol on their lives. This knowledge will empower you to make informed choices about where to invest your time and resources for optimal health outcomes.
**Significance & Impact:** This study holds the potential to revolutionize how we approach metabolic health and weight management. By scientifically validating the Insulin Balance Formula, we aim to provide concrete evidence of its benefits and limitations. The expected outcomes could pave the way for a broader understanding of metabolic balance, offering participants a personalized roadmap to vitality. While the journey is personalized, the impact could be a collective shift towards healthier living.
The Intervention
Included Products & Services
Product Name: Insulin Balance Formula – Hormetics Weight Optimization System – 3 bottles
Quantity included: 90
Price: $117.00
Product Description: The Insulin Balance Formula is for the 'High Insulin Type' who is struggling with weight loss due to insulin resistance, where cells become less responsive to insulin, leading to elevated blood sugar and fat storage. A cornerstone of the Hormetics Weight Optimization System, this product is doctor-formulated by Dr. Miriam Mikicki, MD and Elwin Robinson.
Product Image:
Ingredients:
Who This Is For
The Insulin Balance Formula is crafted for individuals struggling with weight loss due to insulin resistance, where cells become less responsive to insulin, leading to elevated blood sugar and fat storage [2]. This doctor-formulated solution is perfect for:
Adults with stubborn weight gain, particularly around the midsection [3].
Those with metabolic syndrome or prediabetes seeking to enhance insulin sensitivity [4].
Individuals desiring a natural, doctor-formulated approach to hormonal balance and weight management [5].
If diets have failed you or you feel stuck in a cycle of weight gain, this doctor-formulated formula offers a targeted path to reclaim your health.
Benefits of Insulin Balance Formula
Hormetic’s Insulin Balance Formula delivers a range of benefits to support your weight loss and overall wellness:
Enhances Insulin Sensitivity: Improves your body’s response to insulin, reducing blood sugar spikes and fat storage [6].
Promotes Sustainable Weight Loss: Supports fat burning by correcting hormonal imbalances with a doctor-formulated approach [7].
Reduces Cravings: Stabilizes blood sugar to curb sugar cravings and overeating [8].
Supports Metabolic Health: Promotes healthy cholesterol, blood pressure, and energy levels [9].
Optimizes Hormonal Balance: Aligns with the Hormetics Weight Optimization System for comprehensive wellness [10].
Each ingredient is selected for synergy, delivering powerful results backed by science.
Our Ingredients: Science Meets Tradition
The Insulin Balance Formula, doctor-formulated by Dr. Miriam Mikicki, MD, and Elwin Robinson, combines five potent ingredients, each chosen for its proven ability to combat insulin resistance and support weight loss. Sourced from premium suppliers, these ingredients blend ancient wisdom with modern science:
Berberine 500mg
What It Is: Berberine is a bioactive compound extracted from plants like Berberis vulgaris (barberry) [11].
Source: Sustainably harvested from high-quality botanical sources, our Berberine ensures potency in this doctor-formulated formula [12].
History of Use: Used for over 2,000 years in Chinese and Ayurvedic medicine, Berberine is celebrated for its metabolic benefits [13].
Benefits: A 2012 study found Berberine reduced BMI from 31.5 ± 3.6 to 27.4 ± 2.4 kg/m² and leptin levels from 8.01 to 5.12 μg/L in metabolic syndrome patients [14]. This doctor-formulated ingredient activates AMPK, promoting weight loss and insulin sensitivity [15].
Picture of berberine berries
Beta Alanine 500mg
What It Is: Beta Alanine is a non-essential amino acid known for buffering acid in muscles and enhancing metabolic function [16].
Source: Synthesized from natural precursors, our pharmaceutical-grade Beta Alanine ensures purity in this doctor-formulated formula [17].
History of Use: Traditionally used in sports nutrition, Beta Alanine has emerged as a key player in metabolic health [18].
Benefits: A 2021 study found Beta Alanine enhances insulin sensitivity and reduces oxidative stress in metabolic syndrome patients [19]. This ingredient supports energy metabolism, helping you stay active and burn fat [20].
Zinc Citrate 15mg
What It Is: Zinc Citrate is a highly absorbable form of zinc, an essential mineral for hormonal and metabolic health [21].
Source: Sourced from natural mineral deposits, our chelated Zinc Citrate optimizes absorption in this doctor-formulated blend [22].
History of Use: Zinc has been used for centuries in traditional medicine to support immunity and hormonal balance [23].
Benefits: A 2010 study showed zinc improves insulin sensitivity and reduces fasting glucose in insulin-resistant individuals [24]. This ingredient supports healthy lipid profiles and reduces inflammation, aiding weight loss [25].
Folate (L-5-MTHF) 200mcg
What It Is: L-5-Methyltetrahydrofolate (L-5-MTHF), the bioactive form of folate, is a B-vitamin crucial for DNA synthesis and metabolic health [26].
Source: Derived from natural plant-based precursors, our folate is highly bioavailable, ensuring maximum efficacy in this doctor-formulated blend [27].
History of Use: Folate has been used for decades to support cellular health, with recent research highlighting its role in metabolic disorders [28].
Benefits: A 2021 study showed folate improves insulin sensitivity and reduces homocysteine levels in insulin-resistant patients [29]. This ingredient supports blood sugar regulation and reduces inflammation, aiding weight management [30].
Fenugreek Extract 500mg
What It Is: Fenugreek Extract, derived from Trigonella foenum-graecum seeds, is rich in bioactive compounds like saponins [31].
Source: Organically grown and standardized, our Fenugreek ensures consistent potency in this doctor-formulated blend [32].
History of Use: Fenugreek has been used for centuries in Middle Eastern and Indian traditions to support metabolism [33].
Benefits: A 2015 study showed Fenugreek reduces fasting glucose, insulin, and body weight in prediabetic patients [34]. This ingredient stabilizes blood sugar and reduces cravings with its high fiber content [35].
[3] https://pmc.ncbi.nlm.nih.gov/articles/PMC4591578/,
[4] https://pubmed.ncbi.nlm.nih.gov/34371867/,
[5] https://pubmed.ncbi.nlm.nih.gov/34333586/
[6] https://pubmed.ncbi.nlm.nih.gov/22474499/,
[7] https://pmc.ncbi.nlm.nih.gov/articles/PMC4591578/,
[8] https://pubmed.ncbi.nlm.nih.gov/34333586/,
[9] https://pubmed.ncbi.nlm.nih.gov/20045801/,
[10] https://pubmed.ncbi.nlm.nih.gov/34371867/
[11] https://pubmed.ncbi.nlm.nih.gov/22474499/,
[12] https://pubmed.ncbi.nlm.nih.gov/23118793/,
[13] https://pubmed.ncbi.nlm.nih.gov/23118793/,
[14] https://pubmed.ncbi.nlm.nih.gov/22474499/,
[15] https://pubmed.ncbi.nlm.nih.gov/22851982/
[16] https://pubmed.ncbi.nlm.nih.gov/34333586/,
[17] https://pubmed.ncbi.nlm.nih.gov/21847611/,
[18] https://pubmed.ncbi.nlm.nih.gov/21847611/,
[19] https://pubmed.ncbi.nlm.nih.gov/34333586/,
[20] https://pubmed.ncbi.nlm.nih.gov/21847611/
[21] https://pubmed.ncbi.nlm.nih.gov/20045801/,
[22] https://pubmed.ncbi.nlm.nih.gov/17292847/,
[23] https://pubmed.ncbi.nlm.nih.gov/17292847/,
[24] https://pubmed.ncbi.nlm.nih.gov/20045801/,
[25] https://pubmed.ncbi.nlm.nih.gov/19107981/
[26] https://pubmed.ncbi.nlm.nih.gov/34371867/,
[27] https://pubmed.ncbi.nlm.nih.gov/17209196/,
[28] https://pubmed.ncbi.nlm.nih.gov/28724658/,
[29] https://pubmed.ncbi.nlm.nih.gov/34371867/,
[30] https://pubmed.ncbi.nlm.nih.gov/28724658/
[31] https://pmc.ncbi.nlm.nih.gov/articles/PMC4591578/,
[32] https://pubmed.ncbi.nlm.nih.gov/21947880/,
[33] https://pubmed.ncbi.nlm.nih.gov/21947880/,
[34] https://pmc.ncbi.nlm.nih.gov/articles/PMC4591578/,
[35] https://pubmed.ncbi.nlm.nih.gov/16379570/
Product Safety:
Who Shouldn’t Take This Formula
While the Insulin Balance Formula is safe for most adults, certain individuals should avoid it or consult a healthcare provider before using this product:
Pregnant or Nursing Women: The safety of Berberine and Fenugreek during pregnancy or breastfeeding is not established [36].
Individuals on Certain Medications: Berberine may interact with medications like metformin or statins [37].
Those with Low Blood Sugar: This formula may lower blood sugar, so caution is advised for hypoglycemic individuals [38]. Taking the capsules with a meal may help.
People with Allergies: Those allergic to fenugreek or related plants (e.g., peanuts) should avoid this product [39].
Children: This doctor-formulated formula is not intended for individuals under 18 [40].
Consult your healthcare provider before starting this supplement, especially if you have health conditions or take medications.